AMERICA’S #1 PRESCRIBED BRANDED ORAL MEDICATION¹*

Synthroid has been committed to treating hypothyroidism for 63 years.³

It’s America’s #1 prescribed branded oral medication^1*
Millions of patients manage their hypothyroidism with Synthroid^4†

*2015-2018.
^†2015.

ABBVIE IS COMMITTED TO MANUFACTURING INTEGRITY

In August 2002, the FDA released the Current Good Manufacturing Practices (CGMP) initiative to ensure the quality of drug products. The initiative contains minimum requirements for the methods, facilities, and controls used in manufacturing, processing, and packing of a drug product. These regulations make sure that a product is safe for use, and that it has the ingredients and strength it claims to have.^5,6

AbbVie is committed to adhering to the CGMP and believes in the integrity of its manufacturing process. AbbVie is dedicated to ensuring that all Synthroid products are manufactured at the highest standards.

Note that FDA regulations require that all pharmaceutical manufactures like AbbVie abide by CGMP.

ARE PATIENTS GETTING SYNTHROID AS YOU PRESCRIBED?

PREVENTING NONMEDICAL SUBSTITUTION AT THE PHARMACY

DAW codes are codes a pharmacy uses when filling your patient’s prescription. DAW-1 indicates that substitution is not allowed, based on the prescriber’s preference, and ensures your patient will receive the treatment you prescribe. It also helps your patient pay the lowest possible price for the product you write if it is billed through insurance.

When prescribing Synthroid, protecting your script can ensure your patients receive Synthroid every time they refill their prescription.

Dispense as Written (DAW) Synthroid refills

Tablets shown not actual size and may not represent exact color.

Most digital systems require multiple steps to prevent substitution

Select the proper checkboxes. Have you electronically indicated your brand preference?
Ensure state-specific language is indicated in the system, and if applicable, in the signature line, comment, notes, and/or instruction fields
Double-check your work. Most digital systems will default to generic, regardless of the previous script

For written scripts, see examples of state-specific language

Brand Medically Necessary
Dispense as Written
Do Not Substitute
No Substitution
May Not Substitute

Consider the following when switching from Synthroid

Some, but not all, levothyroxine products have been determined to be therapeutically equivalent by the FDA⁹
A levothyroxine product that is not therapeutically equivalent to Synthroid might not have the exact same effect on a patient’s TSH levels as Synthroid¹¹
Switching between nontherapeutically equivalent levothyroxine treatments may lead to¹¹:
- More frequent patient visits
- Additional laboratory tests
All hypothyroidism patients, including those remaining on consistent therapy, should have their TSH tested on a regular basis as recommended by their doctor¹¹

Synthroid has 12 precise dosing options

USE YOUR STATE'S REQUIRED LANGUAGE TO INDICATE A PRESCRIPTION IS DAW-1

INDICATION²

Hypothyroidism
SYNTHROID^® (levothyroxine sodium) tablets, for oral use is indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.

Pituitary Thyrotropin (Thyroid Stimulating Hormone, TSH) Suppression
SYNTHROID is indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

Limitation of Use²

SYNTHROID is not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients, as there are no clinical benefits and over-treatment with SYNTHROID may induce hyperthyroidism.

SYNTHROID is not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.

INDICATION²

Limitation of Use²

SYNTHROID is not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.

INDICATION²

Limitation of Use²

SYNTHROID is not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis.

INDICATION²

Hypothyroidism: SYNTHROID^® (levothyroxine sodium) tablets, for oral use is indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.

IMPORTANT SAFETY INFORMATION²

WARNING:

Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

IMPORTANT SAFETY INFORMATION²

WARNING:

IMPORTANT SAFETY INFORMATION²

WARNING: Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of

IMPORTANT SAFETY INFORMATION²

WARNING: Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of

605-1939428

AMERICA’S #1 PRESCRIBED BRANDED ORAL MEDICATION1*

Synthroid has been committed to treating hypothyroidism for 63 years.3

It’s America’s #1 prescribed branded oral medication1*

Millions of patients manage their hypothyroidism with Synthroid4†

ABBVIE IS COMMITTED TO MANUFACTURING INTEGRITY

ARE PATIENTS GETTING SYNTHROID AS YOU PRESCRIBED?

PREVENTING NONMEDICAL SUBSTITUTION AT THE PHARMACY

Consider the following when switching from Synthroid

Synthroid has 12 precise dosing options

USE YOUR STATE'S REQUIRED LANGUAGE TO INDICATE A PRESCRIPTION IS DAW-1

INDICATION2

Limitation of Use2

INDICATION2

Limitation of Use2

INDICATION2

INDICATION2

Limitation of Use2

INDICATION2

IMPORTANT SAFETY INFORMATION2

WARNING:

IMPORTANT SAFETY INFORMATION2

WARNING:

IMPORTANT SAFETY INFORMATION2

WARNING: Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of

IMPORTANT SAFETY INFORMATION2

WARNING: Thyroid hormones, including SYNTHROID, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of

AMERICA’S #1 PRESCRIBED BRANDED ORAL MEDICATION¹*

Synthroid has been committed to treating hypothyroidism for 63 years.³

It’s America’s #1 prescribed branded oral medication^1*

Millions of patients manage their hypothyroidism with Synthroid^4†

INDICATION²

Limitation of Use²

INDICATION²

Limitation of Use²

INDICATION²

INDICATION²

Limitation of Use²

INDICATION²

IMPORTANT SAFETY INFORMATION²

IMPORTANT SAFETY INFORMATION²

IMPORTANT SAFETY INFORMATION²

IMPORTANT SAFETY INFORMATION²