Synthroid is America’s #1 prescribed branded hypothyroidism medication1,2* Committed to treating hypothyroidism for 70 years3

Millions of patients manage their hypothyroidism with Synthroid2

*Data on file. February 2019 through January 2025.

Individualized treatment from an Endocrinologist

Hear from Dr. Todd Frieze, MD, Associate Professor of Medicine at Duke University as he discusses best practices for treating hypothyroidism with Synthroid. Learn about the importance of precise dosing, consistent medication, and careful monitoring to achieve optimal therapeutic results. See why Synthroid is his treatment of choice for hypothyroidism patients.

Synthroid has 12 precise dosing options to fit your patients' needs1

See precision dosing

AbbVie is committed to manufacturing integrity

Since 1963 the FDA has released pharmaceutical guidelines for Current Good Manufacturing Practices (cGMP). In August 2002, the FDA updated the cGMP to include an initiative to ensure the quality of drug products. This included minimum requirements for the methods, facilities, and controls used in manufacturing, processing, and packing of a drug product. The regulations were created to make sure products are safe for use, and that it has the ingredients and strength it claims to have.4,5

AbbVie is committed to adhering to cGMP and believes in the integrity of its manufacturing process. AbbVie is dedicated to ensuring that all Synthroid products are manufactured at the highest standards.

Note that FDA regulations require that all pharmaceutical manufacturers like AbbVie abide by cGMP.

Synthroid contains no ingredients made from a gluten-containing grain (wheat, barley, or rye).1

Once you have chosen to prescribe brand-name Synthroid

Make sure to protect their script by specifying "Dispense as written" or "DAW"

Are patients getting Synthroid as you prescribed?

32% of patients who think they are taking Synthroid actually are not6

Mistaken generic users defined as those who reported taking Synthroid but did not have “Synthroid” embossed on the pill in a national online survey conducted in 2021 of 1908 adults diagnosed with hypothyroidism and currently taking LT4 products.

That’s because substitutions can be made at the pharmacy if the prescription is not properly protected with the Dispense as Written (DAW) state-specific language.

The FDA has determined that certain levothyroxine products are therapeutically equivalent and can be substituted with the full expectation that the substituted product will produce the same clinical effect and safety profile as the reference product.9

When prescribing Synthroid, include your "DAW" state-specific language to prevent generic substitution

Preventing nonmedical substitution at the pharmacy

DAW codes are codes a pharmacy uses when filling your patient’s prescription. DAW-1 indicates that substitution is not allowed based on the prescriber’s preference, and ensures your patient will receive the treatment you prescribe. It may also help your patient pay a lower price for the product you write if it is billed through insurance.

When prescribing Synthroid, protecting your script can ensure your patients receive Synthroid every time they refill their prescription.

Tablets shown not actual size and may not represent exact color.

Consider the following when switching from Synthroid

  • Most, but not all, levothyroxine products have been determined to be therapeutically equivalent by the FDA9
  • A levothyroxine product that is not therapeutically equivalent to Synthroid might not have the exact same effect on a patient’s TSH levels as Synthroid9
  • Switching between nontherapeutically equivalent levothyroxine treatments may lead to10:
    • More frequent patient visits
    • Additional laboratory tests
  • All hypothyroidism patients, including those remaining on consistent therapy, should have their TSH tested on a regular basis as recommended by their doctor11

Use your state’s required language to indicate a prescription is DAW-1

Language needed to prevent generic substitution varies by state.

Use the drop-down menu below to select your state and see the specific language required to prevent generic substitution.8

Updated as of 01/20/2024. This state-specific information is intended as guidance and suggestions only. This slide does not constitute legal advice and AbbVie is not responsible for providing updates or corrections. Please consult your local authority regarding state specific pharmacy regulations.

When it comes to managing hypothyroidism, precision matters1

Synthroid is available in 12 dosing options.

Discover precision dosing